Chromosomal Translocations in NK-Cell Lymphomas Originate from Inter-Chromosomal Contacts of Active rDNA Clusters Possessing Hot Spots of DSBs

Chromosomal Translocations in NK-Cell Lymphomas Originate from Inter-Chromosomal Contacts of Active rDNA Clusters Possessing Hot Spots of DSBs

Endogenous hot spots of DNA double-strand breaks (DSBs) are tightly linked with transcription patterns and cancer. There are nine hot spots of DSBs (denoted Pleiades) in human rDNA units that are located exclusively inside the intergenic spacer (IGS). Profiles of Pleiades coincide with the profiles...

Full description

Bibliographic Details
Main Authors: Nickolai A. Tchurikov, Leonid A. Uroshlev, Elena S. Klushevskaya, Ildar R. Alembekov, Maria A. Lagarkova, Galina I. Kravatskaya, Vsevolod Y. Makeev, Yuri V. Kravatsky
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
NK-cell lymphomas
T cells
rDNA genes
inter-chromosomal contacts
4C
translocations
Online Access:https://www.mdpi.com/2072-6694/13/15/3889

Internet

https://www.mdpi.com/2072-6694/13/15/3889

Similar Items