The role of cDC1s in vivo: CD8 T cell priming through cross-presentation [version 1; referees: 3 approved]

• Main Authors: Derek Theisen, Kenneth Murphy
• Format: Article
• Language: English
• Published: F1000 Research Ltd 2017-02-01
• Series: F1000Research
• Subjects: Antigen Processing & Recognition; Genetics of the Immune System; Immunity to Infections; Innate Immunity; Leukocyte Activation; Leukocyte Development; Leukocyte Signaling & Gene Expression
• Online Access: https://f1000research.com/articles/6-98/v1

The cDC1 subset of classical dendritic cells is specialized for priming CD8 T cell responses through the process of cross-presentation. The molecular mechanisms of cross-presentation remain incompletely understood because of limited biochemical analysis of rare cDC1 cells, difficulty in their genetic manipulation, and reliance on in vitro systems based on monocyte- and bone-marrow-derived dendritic cells. This review will discuss cross-presentation from the perspective of studies with monocyte- or bone-marrow-derived dendritic cells while highlighting the need for future work examining cDC1 cells. We then discuss the role of cDC1s as a cellular platform to combine antigen processing for class I and class II MHC presentation to allow the integration of “help” from CD4 T cells during priming of CD8 T cell responses.