Tissue Cytokine IL-33 Modulates the Cytotoxic CD8 T Lymphocyte Activity During Nutrient Deprivation by Regulation of Lineage-Specific Differentiation Programs

Tissue Cytokine IL-33 Modulates the Cytotoxic CD8 T Lymphocyte Activity During Nutrient Deprivation by Regulation of Lineage-Specific Differentiation Programs

IL-1 family member IL-33 exerts a variety of immune activating and regulating properties and has recently been proposed as a prognostic biomarker for cancer diseases, although its precise role in tumor immunity is unclear. Here we analyzed in vitro conditions influencing the function of IL-33 as an...

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Bibliographic Details
Main Authors: Caroline Dreis, Florian M. Ottenlinger, Mateusz Putyrski, Andreas Ernst, Meik Huhn, Katrin G. Schmidt, Josef M. Pfeilschifter, Heinfried H. Radeke
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
IL-33
bioactivity
CD8+ T lymphocytes
ST2L
nutrient deprivation
mTOR
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01698/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01698/full

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