The Circulating GRP78/BiP Is a Marker of Metabolic Diseases and Atherosclerosis: Bringing Endoplasmic Reticulum Stress into the Clinical Scenario

The Circulating GRP78/BiP Is a Marker of Metabolic Diseases and Atherosclerosis: Bringing Endoplasmic Reticulum Stress into the Clinical Scenario

Background: Glucose-regulated protein 78/Binding immunoglobulin protein (GRP78/BiP) is a protein associated with endoplasmic reticulum stress and is upregulated by metabolic alterations at the tissue-level, such as hypoxia or glucose deprivation, and it is hyper-expressed in fat tissue of obese indi...

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Bibliographic Details
Main Authors: Josefa Girona, Cèlia Rodríguez-Borjabad, Daiana Ibarretxe, Joan-Carles Vallvé, Raimon Ferré, Mercedes Heras, Ricardo Rodríguez-Calvo, Sandra Guaita-Esteruelas, Neus Martínez-Micaelo, Núria Plana, Lluís Masana
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Journal of Clinical Medicine
Subjects:
grp78/bip
endoplasmic reticulum stress
atherosclerosis
carotid intima–media thickness
obesity
type 2 diabetes
metabolic syndrome
cardiovascular risk
fenofibrate/niacin treatment
Online Access:https://www.mdpi.com/2077-0383/8/11/1793

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https://www.mdpi.com/2077-0383/8/11/1793

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