Airway Epithelial Inflammation In Vitro Augments the Rescue of Mutant CFTR by Current CFTR Modulator Therapies

Airway Epithelial Inflammation In Vitro Augments the Rescue of Mutant CFTR by Current CFTR Modulator Therapies

In cystic fibrosis (CF), defective biogenesis and activity of the cystic fibrosis transmembrane conductance regulator (CFTR) leads to airway dehydration and impaired mucociliary clearance, resulting in chronic airway infection and inflammation. The most common CFTR mutation, F508del, results in a pr...

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Bibliographic Details
Main Authors: Martina Gentzsch, Deborah M. Cholon, Nancy L. Quinney, Mary E. B. Martino, John T. Minges, Susan E. Boyles, Tara N. Guhr Lee, Charles R. Esther, Carla M. P. Ribeiro
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Pharmacology
Subjects:
airway inflammation
CFTR
F508del
CFTR corrector
CFTR potentiator
CFTR rescue
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.628722/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.628722/full

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