Targeting Complement Pathways in Polytrauma- and Sepsis-Induced Multiple-Organ Dysfunction

Targeting Complement Pathways in Polytrauma- and Sepsis-Induced Multiple-Organ Dysfunction

Exposure to traumatic or infectious insults results in a rapid activation of the complement cascade as major fluid defense system of innate immunity. The complement system acts as a master alarm system during the molecular danger response after trauma and significantly contributes to the clearance o...

Full description

Bibliographic Details
Main Authors: Ebru Karasu, Bo Nilsson, Jörg Köhl, John D. Lambris, Markus Huber-Lang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
trauma
sepsis
hemorrhagic shock
MODS
complement activation
complement dysregulation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00543/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00543/full

Similar Items