Alpha-Synuclein Amyloid Aggregation Is Inhibited by Sulfated Aromatic Polymers and Pyridinium Polycation

Alpha-Synuclein Amyloid Aggregation Is Inhibited by Sulfated Aromatic Polymers and Pyridinium Polycation

The effect of a range of synthetic charged polymers on alpha-synuclein aggregation and amyloid formation was tested. Sulfated aromatic polymers, poly(styrene sulfonate) and poly(anethole sulfonate), have been found to suppress the fibril formation. In this case, small soluble complexes, which do not...

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Bibliographic Details
Main Authors: Pavel Semenyuk, Lidia Kurochkina, Kseniya Barinova, Vladimir Muronetz
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Polymers
Subjects:
polyelectrolyte
sulfated polymers
alpha-synuclein
amyloid aggregation
protein aggregation
artificial chaperone
Online Access:https://www.mdpi.com/2073-4360/12/3/517

Internet

https://www.mdpi.com/2073-4360/12/3/517

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