2-Amido-3-(1H-Indol-3-yl)-N-Substitued-Propanamides as a New Class of Falcipain-2 Inhibitors. 1. Design, Synthesis, Biological Evaluation and Binding Model Studies
The Plasmodium falciparum cysteine protease falcipain-2 (FP-2) is an important cysteine protease and an essential hemoglobinase of erythrocytic P. falciparum trophozoites. The discovery of new FP-2 inhibitors is now a hot topic in the search for potential malaria treatments. In this study, a series...
Main Authors: | Tong Chen, Jin Zhu, Peng Che, Lili Chen, Weiqiang Lu, Jin Huang, Jian Li, Honglin Li, Hualiang Jiang |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2009-01-01
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Series: | Molecules |
Subjects: | |
Online Access: | http://www.mdpi.com/1420-3049/14/1/494/ |
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