Potential treatment of COVID-19 by inhibitors of human dihydroorotate dehydrogenase

by Yechun Xu, Hualiang Jiang
Published 2020-08-01

Computational Studies on Acetylcholinesterases

by Yechun Xu, Shanmei Cheng, Joel L. Sussman, Israel Silman, Hualiang Jiang
Published 2017-08-01

Improving the Virtual Screening Ability of Target-Specific Scoring Functions Using Deep Learning Methods

by Dingyan Wang, Dingyan Wang, Chen Cui, Chen Cui, Xiaoyu Ding, Xiaoyu Ding, Zhaoping Xiong, Mingyue Zheng, Xiaomin Luo, Hualiang Jiang, Hualiang Jiang, Kaixian Chen, Kaixian Chen
Published 2019-08-01

A Statistical Thermodynamic Model for Ligands Interacting With Ion Channels: Theoretical Model and Experimental Validation of the KCNQ2 Channel

by Fang Bai, Fang Bai, Xiaoping Pi, Xiaoping Pi, Ping Li, Pingzheng Zhou, Huaiyu Yang, Xicheng Wang, Min Li, Zhaobing Gao, Zhaobing Gao, Hualiang Jiang, Hualiang Jiang
Published 2018-03-01

Exploring the RING-catalyzed ubiquitin transfer mechanism by MD and QM/MM calculations.

by Yunmei Zhen, Guangrong Qin, Cheng Luo, Hualiang Jiang, Kunqian Yu, Guanghui Chen
Published 2014-01-01

Lys169 of human glucokinase is a determinant for glucose phosphorylation: implication for the atomic mechanism of glucokinase catalysis.

by Jian Zhang, Chenjing Li, Ting Shi, Kaixian Chen, Xu Shen, Hualiang Jiang
Published 2009-07-01

‘One-pot’ Synthesis of Dihydrobenzo[4,5][1,3]oxazino[2,3-a] isoquinolines via a Silver(I)-Catalyzed Cascade Approach

by Jian Li, Hong Liu, Qingya Kong, Hualiang Jiang, Yu Zhou, Baifeng Jiang
Published 2013-01-01

Mechanics of channel gating of the nicotinic acetylcholine receptor.

by Xinli Liu, Yechun Xu, Honglin Li, Xicheng Wang, Hualiang Jiang, Francisco J Barrantes
Published 2008-01-01

Molecular determinants of magnolol targeting both RXRα and PPARγ.

by Haitao Zhang, Xing Xu, Lili Chen, Jing Chen, Lihong Hu, Hualiang Jiang, Xu Shen
Published 2011-01-01

DC260126: a small-molecule antagonist of GPR40 that protects against pancreatic β-Cells dysfunction in db/db mice.

by Peng Sun, Ting Wang, Yuren Zhou, Hong Liu, Hualiang Jiang, Weiliang Zhu, Heyao Wang
Published 2013-01-01

Arctigenin efficiently enhanced sedentary mice treadmill endurance.

by Xuan Tang, Jingjing Zhuang, Jing Chen, Liang Yu, Lihong Hu, Hualiang Jiang, Xu Shen
Published 2011-01-01

Microwave-Assisted One-Pot Synthesis of Pyrazolone Derivatives under Solvent-Free Conditions

by Ruoqun Ma, Jin Zhu, Jie Liu, Lili Chen, Xu Shen, Hualiang Jiang, Jian Li
Published 2010-05-01

A Genetic Algorithm Based Support Vector Machine Model for Blood-Brain Barrier Penetration Prediction

by Daqing Zhang, Jianfeng Xiao, Nannan Zhou, Mingyue Zheng, Xiaomin Luo, Hualiang Jiang, Kaixian Chen
Published 2015-01-01

Understanding Voltage Gating of Providencia stuartii Porins at Atomic Level.

by Wanling Song, Harsha Bajaj, Chady Nasrallah, Hualiang Jiang, Mathias Winterhalter, Jacques-Philippe Colletier, Yechun Xu
Published 2015-05-01

Inherent dynamics of the acid-sensing ion channel 1 correlates with the gating mechanism.

by Huaiyu Yang, Ye Yu, Wei-Guang Li, Fang Yu, Hui Cao, Tian-Le Xu, Hualiang Jiang
Published 2009-07-01

Discovery of selective inhibitors against EBNA1 via high throughput in silico virtual screening.

by Ning Li, Scott Thompson, David C Schultz, Weiliang Zhu, Hualiang Jiang, Cheng Luo, Paul M Lieberman
Published 2010-04-01

Structure-activity relationship and substrate-dependent phenomena in effects of ginsenosides on activities of drug-metabolizing P450 enzymes.

by Miao Hao, Yuqing Zhao, Peizhan Chen, He Huang, Hong Liu, Hualiang Jiang, Ruiwen Zhang, Hui Wang
Published 2008-07-01

Discovery of a Novel CCR5 Antagonist Lead Compound Through Fragment Assembly

by Hualiang Jiang, Jian Li, Xin Xie, Yu Zhang, Jin Zhu, Kunqian Yu, Enkun Zhou, Yanqing Liu
Published 2008-10-01

Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives (THPBs) as proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators for the treat...

by Chenglin Wu, Cong Xi, Junhua Tong, Jing Zhao, Hualiang Jiang, Jiang Wang, Yiping Wang, Hong Liu
Published 2019-11-01

A hybrid framework for improving uncertainty quantification in deep learning-based QSAR regression modeling

by Dingyan Wang, Jie Yu, Lifan Chen, Xutong Li, Hualiang Jiang, Kaixian Chen, Mingyue Zheng, Xiaomin Luo
Published 2021-09-01