Targeting the NFAT1-MDM2-MDMX Network Inhibits the Proliferation and Invasion of Prostate Cancer Cells, Independent of p53 and Androgen

by Jiang-Jiang Qin, Jiang-Jiang Qin, Xin Li, Xin Li, Wei Wang, Wei Wang, Wei Wang, Xiaolin Zi, Xiaolin Zi, Ruiwen Zhang, Ruiwen Zhang, Ruiwen Zhang
Published 2017-12-01

Inhibiting β-Catenin by β-Carboline-Type MDM2 Inhibitor for Pancreatic Cancer Therapy

by Jiang-Jiang Qin, Wei Wang, Wei Wang, Xin Li, Hemantkumar Deokar, John K. Buolamwini, Ruiwen Zhang, Ruiwen Zhang
Published 2018-01-01

Two Birds with One Stone: NFAT1-MDM2 Dual Inhibitors for Cancer Therapy

by Wei Wang, Atif Zafar, Mehrdad Rajaei, Ruiwen Zhang
Published 2020-05-01

Natural products targeting the p53-MDM2 pathway and mutant p53: Recent advances and implications in cancer medicine

by Jiang-Jiang Qin, Xin Li, Courtney Hunt, Wei Wang, Hui Wang, Ruiwen Zhang
Published 2018-09-01

Projected Spatiotemporal Dynamics of Drought under Global Warming in Central Asia

by Ruiwen Zhang, Chengyi Zhao, Xiaofei Ma, Karthikeyan Brindha, Qifei Han, Chaofan Li, Xiaoning Zhao
Published 2019-08-01

Genomic Space of <i>MGMT</i> in Human Glioma Revisited: Novel Motifs, Regulatory RNAs, NRF1, 2, and CTCF Involvement in Gene Expression

by Mohammed A. Ibrahim Al-Obaide, Viswanath Arutla, Manny D. Bacolod, Wei Wang, Ruiwen Zhang, Kalkunte S. Srivenugopal
Published 2021-03-01

Structure-activity relationship and substrate-dependent phenomena in effects of ginsenosides on activities of drug-metabolizing P450 enzymes.

by Miao Hao, Yuqing Zhao, Peizhan Chen, He Huang, Hong Liu, Hualiang Jiang, Ruiwen Zhang, Hui Wang
Published 2008-07-01

JKA97, a novel benzylidene analog of harmine, exerts anti-cancer effects by inducing G1 arrest, apoptosis, and p53-independent up-regulation of p21.

by Xinyi Yang, Wei Wang, Jiang-Jiang Qin, Ming-Hai Wang, Horrick Sharma, John K Buolamwini, Hui Wang, Ruiwen Zhang
Published 2012-01-01

Natural product ginsenoside 25-OCH3-PPD inhibits breast cancer growth and metastasis through down-regulating MDM2.

by Wei Wang, Xu Zhang, Jiang-Jiang Qin, Sukesh Voruganti, Subhasree Ashok Nag, Ming-Hai Wang, Hui Wang, Ruiwen Zhang
Published 2012-01-01

Targeted Brain Tumor Therapy by Inhibiting the MDM2 Oncogene: In Vitro and In Vivo Antitumor Activity and Mechanism of Action

by Surendra R. Punganuru, Viswanath Artula, Wei Zhao, Mehrdad Rajaei, Hemantkumar Deokar, Ruiwen Zhang, John K. Buolamwini, Kalkunte S. Srivenugopal, Wei Wang
Published 2020-07-01

Corrigendum to “A novel inhibitor of MDM2 oncogene blocks metastasis of hepatocellular carcinoma and overcomes chemoresistance” [Genes Dis 694 (2019) 419–430]

by Wei Wang, Bo Hu, Jiang-Jiang Qin, Jianwen Cheng, Xin Li, Mehrdad Rajaei, Jia Fan, Xin-Rong Yang, Ruiwen Zhang
Published 2020-03-01

A novel inhibitor of MDM2 oncogene blocks metastasis of hepatocellular carcinoma and overcomes chemoresistance

by Wei Wang, Bo Hu, Jiang-Jiang Qin, Jian-Wen Cheng, Xin Li, Mehrdad Rajaei, Jia Fan, Xin-Rong Yang, Ruiwen Zhang
Published 2019-12-01

Preclinical Evaluation of Anticancer Efficacy and Pharmacological Properties of FBA-TPQ, a Novel Synthetic Makaluvamine Analog

by Sadanandan E. Velu, Ming-Hai Wang, Ruiwen Zhang, Wei Wang, Dwayaja H. Nadkarni, Sukesh Voruganti, Srinivasan Murugesan, Xu Zhang, Xiangrong Zhang, Hongxia Xu
Published 2012-05-01

Targeting MDM2 for Neuroblastoma Therapy: In Vitro and In Vivo Anticancer Activity and Mechanism of Action

by Wei Wang, Xinjie Wang, Mehrdad Rajaei, Ji Youn Youn, Atif Zafar, Hemantkumar Deokar, John K. Buolamwini, Jianhua Yang, Jennifer H. Foster, Jia Zhou, Ruiwen Zhang
Published 2020-12-01

Does curve pattern impact on the effects of physiotherapeutic scoliosis specific exercises on Cobb angles of participants with adolescent idiopathic scoliosis: A prospective clinic...

by Yunli Fan, Michael K T To, Eric H K Yeung, Jianbin Wu, Rong He, Zhuoman Xu, Ruiwen Zhang, Guangshuo Li, Kenneth M C Cheung, Jason P Y Cheung
Published 2021-01-01

Experimental therapy of ovarian cancer with synthetic makaluvamine analog: in vitro and in vivo anticancer activity and molecular mechanisms of action.

by Tao Chen, Yi Xu, He Guo, Yanling Liu, Pingting Hu, Xinying Yang, Xiaoguang Li, Shichao Ge, Sadanandan E Velu, Dwayaja H Nadkarni, Wei Wang, Ruiwen Zhang, Hui Wang
Published 2011-01-01

Preclinical Pharmacology of BA-TPQ, a Novel Synthetic Iminoquinone Anticancer Agent

by Ruiwen Zhang, Wei Wang, Sadanandan E. Velu, Xinyi Yang, Charnell I. Sommers, Elizabeth R. Rayburn, Xu Zhang, Evrim Gurpinar, Hongxia Xu, Xiangrong Zhang, Scharri J. Ezell, Haibo Li
Published 2010-07-01

KCN1, a novel synthetic sulfonamide anticancer agent: in vitro and in vivo anti-pancreatic cancer activities and preclinical pharmacology.

by Wei Wang, Lin Ao, Elizabeth R Rayburn, Hongxia Xu, Xiangrong Zhang, Xu Zhang, Subhasree Ashok Nag, Xuming Wu, Ming-Hai Wang, Hui Wang, Erwin G Van Meir, Ruiwen Zhang
Published 2012-01-01