Gallic Acid Alleviates Neuropathic Pain Behaviors in Rats by Inhibiting P2X7 Receptor-Mediated NF-κB/STAT3 Signaling Pathway

Gallic Acid Alleviates Neuropathic Pain Behaviors in Rats by Inhibiting P2X7 Receptor-Mediated NF-κB/STAT3 Signaling Pathway

Neuropathic pain is a complex disease with high incidence. Adenosine triphosphate (ATP) and its activated P2X7 receptor are involved in the signal transmission of neuropathic pain. Gallic acid (3,4,5-trihydroxybenzoic acid) is a traditional Chinese medicine obtained from natural plants that exhibit...

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Bibliographic Details
Main Authors: Runan Yang, Zijing Li, Yuting Zou, Jingjian Yang, Lin Li, Xiumei Xu, Günther Schmalzing, Hong Nie, Guilin Li, Shuangmei Liu, Shangdong Liang, Changshui Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Pharmacology
Subjects:
neuropathic pain
chronic constriction injury
P2X7 receptor
gallic acid
dorsal root ganglia
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.680139/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.680139/full

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