A hypothetical trivalent epigenetic code that affects the nature of human ESCs.

It has been suggested that DNA methylation can work in concert with other epigenetic factors, leading to changes in cellular phenotypes. For example, DNA demethylation modifications producing 5-hydroxymethylcytosine (5hmC) are thought to interact with histone modifications to influence the acquisiti...

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Bibliographic Details
Main Authors: Yasuhisa Ishikawa, Kenta Nakai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0238742