Contactin-2, a synaptic and axonal protein, is reduced in cerebrospinal fluid and brain tissue in Alzheimer’s disease

Contactin-2, a synaptic and axonal protein, is reduced in cerebrospinal fluid and brain tissue in Alzheimer’s disease

Abstract Background Synaptic and axonal loss are two major mechanisms underlying Alzheimer’s disease (AD) pathogenesis, and biomarkers reflecting changes in these cellular processes are needed for early diagnosis and monitoring the progression of AD. Contactin-2 is a synaptic and axonal membrane pro...

Full description

Bibliographic Details
Main Authors: Madhurima Chatterjee, Marta Del Campo, Tjado H. J. Morrema, Matthijs de Waal, Wiesje M. van der Flier, Jeroen J. M. Hoozemans, Charlotte E. Teunissen
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Alzheimer’s Research & Therapy
Subjects:
Contactin-2
Alzheimer’s disease (AD)
CSF biomarker
Tau
Neurogranin
Beta secretase 1
Online Access:http://link.springer.com/article/10.1186/s13195-018-0383-x

Internet

http://link.springer.com/article/10.1186/s13195-018-0383-x

Similar Items