Specific features of l-histidine production by Escherichia coli concerned with feedback control of AICAR formation and inorganic phosphate/metal transport

Specific features of l-histidine production by Escherichia coli concerned with feedback control of AICAR formation and inorganic phosphate/metal transport

Abstract Background In the l-histidine (His) biosynthetic pathway of Escherichia coli, the first key enzyme, ATP-phosphoribosyltransferase (ATP-PRT, HisG), is subject to different types of inhibition. Eliminating the feedback inhibition of HisG by the His end product is an important step that enable...

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Bibliographic Details
Main Authors: Evgeniya A. Malykh, Ivan A. Butov, Anna B. Ravcheeva, Alexander A. Krylov, Sergey V. Mashko, Nataliya V. Stoynova
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Microbial Cell Factories
Subjects:
l -Histidine
Inorganic phosphate/metal transport
ATP-phosphoribosyltransferase
AICAR (ZMP)
PitA
Pho regulon
Online Access:http://link.springer.com/article/10.1186/s12934-018-0890-2

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http://link.springer.com/article/10.1186/s12934-018-0890-2

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