Causal Associations of Urate With Cardiovascular Risk Factors: Two-Sample Mendelian Randomization

Causal Associations of Urate With Cardiovascular Risk Factors: Two-Sample Mendelian Randomization

BackgroundMendelian Randomization (MR) studies show conflicting causal associations of genetically predicted serum urate with cardiovascular risk factors (i.e., hypertension, diabetes, lipid profile, and kidney function). This study aimed to robustly investigate a causal relationship between urate a...

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Bibliographic Details
Main Authors: Thitiya Lukkunaprasit, Sasivimol Rattanasiri, Boonsong Ongphiphadhanakul, Gareth J. McKay, John Attia, Ammarin Thakkinstian
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Genetics
Subjects:
cardiovascular risk factor
instrumental variable
Mendelian Randomization
urate
urate transporter gene
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.687279/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2021.687279/full

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