Early Postnatal but Not Late Adult Neurogenesis Is Impaired in the Pitx3-Mutant Animal Model of Parkinson's Disease

The generation of new neurons in the adult dentate gyrus has functional implications for hippocampal formation. Reduced hippocampal neurogenesis has been described in various animal models of hippocampal dysfunction such as dementia and depression, which are both common non-motor-symptoms of Parkins...

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Bibliographic Details
Main Authors: Moritz D. Brandt, Diana Krüger-Gerlach, Andreas Hermann, Anne K. Meyer, Kwang-Soo Kim, Alexander Storch
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Neuroscience
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Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2017.00471/full