Discrimination of Methionine Sulfoxide and Sulfone by Human Neutrophil Elastase

Discrimination of Methionine Sulfoxide and Sulfone by Human Neutrophil Elastase

Human neutrophil elastase (HNE) is a uniquely destructive serine protease with the ability to unleash a wave of proteolytic activity by destroying the inhibitors of other proteases. Although this phenomenon forms an important part of the innate immune response to invading pathogens, it is responsibl...

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Bibliographic Details
Main Authors: Darren Leahy, Cameron Grant, Alex Jackson, Alex Duff, Nicholas Tardiota, Jessica Van Haeften, Xingchen Chen, Jonathan M. Peake, Michael D. Kruppa, Eliot T. Smith, David A. Johnson, William B. Lott, Jonathan M. Harris
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Molecules
Subjects:
human neutrophil elastase
peptide aldehyde
substrate guided inhibitor design
methionine oxidation
methionine sulfone
substrate selectivity
Online Access:https://www.mdpi.com/1420-3049/26/17/5344

Internet

https://www.mdpi.com/1420-3049/26/17/5344

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