Gap Junction-Mediated Intercellular Communication of cAMP Prevents CDDP-Induced Ototoxicity via cAMP/PKA/CREB Pathway

Gap Junction-Mediated Intercellular Communication of cAMP Prevents CDDP-Induced Ototoxicity via cAMP/PKA/CREB Pathway

In the cochlea, non-sensory supporting cells are directly connected to adjacent supporting cells via gap junctions that allow the exchange of small molecules. We have previously shown that the pharmacological regulation of gap junctions alleviates cisplatin (CDDP)-induced ototoxicity in animal model...

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Bibliographic Details
Main Authors: Yeon Ju Kim, Jin-Sol Lee, Hantai Kim, Jeong Hun Jang, Yun-Hoon Choung
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
cisplatin
ototoxicity
gap junction
cAMP
forskolin
all-trans retinoic acid
Online Access:https://www.mdpi.com/1422-0067/22/12/6327

Internet

https://www.mdpi.com/1422-0067/22/12/6327

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