Inhibition of prolyl hydroxylases increases hepatic insulin and decreases glucagon sensitivity by an HIF-2α-dependent mechanism

Inhibition of prolyl hydroxylases increases hepatic insulin and decreases glucagon sensitivity by an HIF-2α-dependent mechanism

Objective: Recent evidence indicates that inhibition of prolyl hydroxylase domain (PHD) proteins can exert beneficial effects to improve metabolic abnormalities in mice and humans. However, the underlying mechanisms are not clearly understood. This study was designed to address this question. Method...

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Bibliographic Details
Main Authors: Matthew Riopel, Jae-Su Moon, Gautam K. Bandyopadhyay, Seohee You, Kevin Lam, Xiao Liu, Tatiana Kisseleva, David Brenner, Yun Sok Lee
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Molecular Metabolism
Subjects:
Obesity-induced glucose intolerance
Type 2 diabetes
Liver glucagon sensitivity
Prolyl hydroxylase domain (PHD) enzymes
Insulin
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877820301137

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http://www.sciencedirect.com/science/article/pii/S2212877820301137

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