Inhibiting HMGB1-RAGE axis prevents pro-inflammatory macrophages/microglia polarization and affords neuroprotection after spinal cord injury

Inhibiting HMGB1-RAGE axis prevents pro-inflammatory macrophages/microglia polarization and affords neuroprotection after spinal cord injury

Abstract Background Spinal cord injury (SCI) favors a persistent pro-inflammatory macrophages/microglia-mediated response with only a transient appearance of anti-inflammatory phenotype of immune cells. However, the mechanisms controlling this special sterile inflammation after SCI are still not ful...

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Bibliographic Details
Main Authors: Hong Fan, Hai-Bin Tang, Zhe Chen, Hu-Qing Wang, Lei Zhang, Yu Jiang, Tao Li, Cai-Feng Yang, Xiao-Ya Wang, Xia Li, Sheng-Xi Wu, Gui-Lian Zhang
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Journal of Neuroinflammation
Subjects:
Spinal cord injury
Macrophages/microglia
HMGB1
Polarization
RAGE
Online Access:http://link.springer.com/article/10.1186/s12974-020-01973-4

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http://link.springer.com/article/10.1186/s12974-020-01973-4

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