CD8+ cytotoxic T cell responses to dominant tumor-associated antigens are profoundly weakened by aging yet subdominant responses retain functionality and expand in response to chemotherapy

CD8+ cytotoxic T cell responses to dominant tumor-associated antigens are profoundly weakened by aging yet subdominant responses retain functionality and expand in response to chemotherapy

Increasing life expectancy is associated with increased cancer incidence, yet the effect of cancer and anti-cancer treatment on elderly patients and their immune systems is not well understood. Declining T cell function with aging in response to infection and vaccination is well documented, however...

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Bibliographic Details
Main Authors: Connie Jackaman, Joanne K. Gardner, Federica Tomay, Joshua Spowart, Hannah Crabb, Danielle E. Dye, Simon Fox, Stephen Proksch, Pat Metharom, Satvinder S. Dhaliwal, Delia J. Nelson
Format: Article
Language:English
Published: Taylor & Francis Group 2019-04-01
Series:OncoImmunology
Subjects:
solid tumors
standard chemotherapy
hierarchical t cell responses
elderly hosts with cancer
mesothelioma
dominant and subdominant cd8+ t cell responses
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1564452

Internet

http://dx.doi.org/10.1080/2162402X.2018.1564452

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