The Conserved RNA Exonuclease Rexo5 Is Required for 3′ End Maturation of 28S rRNA, 5S rRNA, and snoRNAs

The Conserved RNA Exonuclease Rexo5 Is Required for 3′ End Maturation of 28S rRNA, 5S rRNA, and snoRNAs

Non-coding RNA biogenesis in higher eukaryotes has not been fully characterized. Here, we studied the Drosophila melanogaster Rexo5 (CG8368) protein, a metazoan-specific member of the DEDDh 3′-5′ single-stranded RNA exonucleases, by genetic, biochemical, and RNA-sequencing approaches. Rexo5 is requi...

Full description

Bibliographic Details
Main Authors: Stefanie Gerstberger, Cindy Meyer, Sigi Benjamin-Hong, Joe Rodriguez, Daniel Briskin, Claudia Bognanni, Kimberly Bogardus, Hermann Steller, Thomas Tuschl
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Cell Reports
Subjects:
rRNA biogenesis
rRNA 3′ end maturation
rRNA processing
snoRNA biogenesis
snoRNA 3′ end maturation
snoRNA processing
RNA exonuclease
U8 snoRNA
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717313724

Internet

http://www.sciencedirect.com/science/article/pii/S2211124717313724

Similar Items