Characterization of highly frequent epitope-specific CD45RA<sup>+</sup>/CCR7<sup>+/- </sup>T lymphocyte responses against p53-binding domains of the human polyomavirus BK large tumor antigen in HLA-A*0201+ BKV-seropositive donors

Characterization of highly frequent epitope-specific CD45RA<sup>+</sup>/CCR7<sup>+/- </sup>T lymphocyte responses against p53-binding domains of the human polyomavirus BK large tumor antigen in HLA-A*0201+ BKV-seropositive donors

<p>Abstract</p> <p>Human polyomavirus BK (BKV) has been implicated in oncogenic transformation. Its ability to replicate is determined by the binding of its large tumor antigen (LTag) to products of tumor-suppressor genes regulating cell cycle, as specifically p53. We investigated...

Full description

Bibliographic Details
Main Authors: Zajac Paul, Gosert Rainer, Sais Giovanni, Hudolin Tvrtko, Wyler Stephen, Bracci Laura, Provenzano Maurizio, Palu' Giorgio, Heberer Michael, Hirsch Hans H, Spagnoli Giulio C
Format: Article
Language:English
Published: BMC 2006-11-01
Series:Journal of Translational Medicine
Online Access:http://www.translational-medicine.com/content/4/1/47

Internet

http://www.translational-medicine.com/content/4/1/47

Similar Items