Inherited and Acquired Determinants of Hepatic CYP3A Activity in Humans

Inherited and Acquired Determinants of Hepatic CYP3A Activity in Humans

Human CYP3A enzymes (including CYP3A4 and CYP4A5) metabolize about 40% of all drugs and numerous other environmental and endogenous substances. CYP3A activity is highly variable within and between humans. As a consequence, therapy with standard doses often results in too low or too high blood and ti...

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Bibliographic Details
Main Authors: Johannes Matthaei, Wagner Hugo Bonat, Reinhold Kerb, Mladen Vassilev Tzvetkov, Jakob Strube, Stefanie Brunke, Cordula Sachse-Seeboth, Daniel Sehrt, Ute Hofmann, Jacob von Bornemann Hjelmborg, Matthias Schwab, Jürgen Brockmöller
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Genetics
Subjects:
CYP3A
CYP3A4
CYP3A5
midazolam
4ß-OH-cholesterol
6ß-OH-cortisol
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.00944/full

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https://www.frontiersin.org/article/10.3389/fgene.2020.00944/full

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