Pilot Production of Mesenchymal Stem/Stromal Freeze-Dried Secretome for Cell-Free Regenerative Nanomedicine: A Validated GMP-Compliant Process

Pilot Production of Mesenchymal Stem/Stromal Freeze-Dried Secretome for Cell-Free Regenerative Nanomedicine: A Validated GMP-Compliant Process

In this paper, a pilot production process for mesenchymal stem/stromal freeze-dried secretome was performed in a validated good manufacturing practice (GMP)-compliant cell factory. Secretome was purified from culture supernatants by ultrafiltration, added to cryoprotectant, lyophilized and character...

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Bibliographic Details
Main Authors: Elia Bari, Sara Perteghella, Dario Di Silvestre, Marzio Sorlini, Laura Catenacci, Milena Sorrenti, Giorgio Marrubini, Rossana Rossi, Giuseppe Tripodo, Pierluigi Mauri, Mario Marazzi, Maria Luisa Torre
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Cells
Subjects:
exosome
microvesicles
ultrafiltration
freeze-drying
secretome
mesenchymal stem cells
Online Access:https://www.mdpi.com/2073-4409/7/11/190

Internet

https://www.mdpi.com/2073-4409/7/11/190

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