PureCLIP: capturing target-specific protein–RNA interaction footprints from single-nucleotide CLIP-seq data

PureCLIP: capturing target-specific protein–RNA interaction footprints from single-nucleotide CLIP-seq data

Abstract The iCLIP and eCLIP techniques facilitate the detection of protein–RNA interaction sites at high resolution, based on diagnostic events at crosslink sites. However, previous methods do not explicitly model the specifics of iCLIP and eCLIP truncation patterns and possible biases. We develope...

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Bibliographic Details
Main Authors: Sabrina Krakau, Hugues Richard, Annalisa Marsico
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Genome Biology
Subjects:
Protein–RNA interaction
iCLIP-seq
eCLIP-seq
Crosslink sites
Hidden Markov model
Online Access:http://link.springer.com/article/10.1186/s13059-017-1364-2

Internet

http://link.springer.com/article/10.1186/s13059-017-1364-2

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