Targeting HER2-breast tumors with scFv-decorated bimodal nanoprobes

Targeting HER2-breast tumors with scFv-decorated bimodal nanoprobes

Abstract Background Recent advances in nanomedicine have shown the great interest of active targeting associated to nanoparticles. Single chain variable fragments (scFv) of disease-specific antibodies are very promising targeting entities because they are small, not immunogenic and able to bind thei...

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Bibliographic Details
Main Authors: Christophe Alric, Katel Hervé-Aubert, Nicolas Aubrey, Souad Melouk, Laurie Lajoie, William Même, Sandra Même, Yann Courbebaisse, Anastasia A. Ignatova, Alexey V. Feofanov, Igor Chourpa, Emilie Allard-Vannier
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Journal of Nanobiotechnology
Subjects:
Breast tumor
Human Epithelial growth Receptor 2 (HER2)
Iron oxide nanoparticle
Cyanine 5.5
Single chain variable fragment (scFv)
Magnetic Resonance Imaging (MRI)
Online Access:http://link.springer.com/article/10.1186/s12951-018-0341-6

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http://link.springer.com/article/10.1186/s12951-018-0341-6

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