Lithium Suppresses Hedgehog Signaling via Promoting ITCH E3 Ligase Activity and Gli1–SUFU Interaction in PDA Cells

Lithium Suppresses Hedgehog Signaling via Promoting ITCH E3 Ligase Activity and Gli1–SUFU Interaction in PDA Cells

Dysregulation of Hedgehog (Hh) signaling pathway is one of the hallmarks of pancreatic ductal adenocarcinoma (PDA). Lithium, a clinical mood stabilizer for the treatment of mental disorders, is known to suppress tumorigenic potential of PDA cells by targeting the Hh/Gli signaling pathway. In this st...

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Bibliographic Details
Main Authors: Xinshuo Wang, Zijian Fang, Anlin Wang, Cheng Luo, Xiaodong Cheng, Meiling Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Pharmacology
Subjects:
Gli1
lithium
ITCH
GSK3β
pancreatic cancer
ubiquitination
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00820/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00820/full

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