ER Stress Inhibits Liver Fatty Acid Oxidation while Unmitigated Stress Leads to Anorexia-Induced Lipolysis and Both Liver and Kidney Steatosis

ER Stress Inhibits Liver Fatty Acid Oxidation while Unmitigated Stress Leads to Anorexia-Induced Lipolysis and Both Liver and Kidney Steatosis

The unfolded protein response (UPR), induced by endoplasmic reticulum (ER) stress, regulates the expression of factors that restore protein folding homeostasis. However, in the liver and kidney, ER stress also leads to lipid accumulation, accompanied at least in the liver by transcriptional suppress...

Full description

Bibliographic Details
Main Authors: Diane DeZwaan-McCabe, Ryan D. Sheldon, Michelle C. Gorecki, Deng-Fu Guo, Erica R. Gansemer, Randal J. Kaufman, Kamal Rahmouni, Matthew P. Gillum, Eric B. Taylor, Lynn M. Teesch, D. Thomas Rutkowski
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:Cell Reports
Subjects:
ER stress
unfolded protein response
fatty liver
fatty kidney
fatty acid oxidation
lipolysis
lipidomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717306459

Internet

http://www.sciencedirect.com/science/article/pii/S2211124717306459

Similar Items