GlialCAM/MLC1 modulates LRRC8/VRAC currents in an indirect manner: Implications for megalencephalic leukoencephalopathy

GlialCAM/MLC1 modulates LRRC8/VRAC currents in an indirect manner: Implications for megalencephalic leukoencephalopathy

Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare type of leukodystrophy caused by mutations in either MLC1 or GLIALCAM genes. Previous work indicated that chloride currents mediated by the volume-regulated anion channel (VRAC) and ClC-2 channels were affected in astrocytes...

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Bibliographic Details
Main Authors: Xabier Elorza-Vidal, Sònia Sirisi, Héctor Gaitán-Peñas, Carla Pérez-Rius, Marta Alonso-Gardón, Mercedes Armand-Ugón, Angela Lanciotti, Maria Stefania Brignone, Esther Prat, Virginia Nunes, Elena Ambrosini, Xavier Gasull, Raúl Estévez
Format: Article
Language:English
Published: Elsevier 2018-11-01
Series:Neurobiology of Disease
Subjects:
Leukodystrophy
MLC1
GlialCAM
LRRC8
Astrocytes
Signal transduction
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118303498

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http://www.sciencedirect.com/science/article/pii/S0969996118303498

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