Development and Application of Sub-Mitochondrial Targeted Ca2 + Biosensors

Development and Application of Sub-Mitochondrial Targeted Ca2 + Biosensors

Mitochondrial Ca2+ uptake into the mitochondrial matrix is a well-established mechanism. However, the sub-organellar Ca2+ kinetics remain elusive. In the present work we identified novel site-specific targeting sequences for the intermembrane space (IMS) and the cristae lumen (CL). We used these nov...

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Bibliographic Details
Main Authors: Markus Waldeck-Weiermair, Benjamin Gottschalk, Corina T. Madreiter-Sokolowski, Jeta Ramadani-Muja, Gabriela Ziomek, Christiane Klec, Sandra Burgstaller, Helmut Bischof, Maria R. Depaoli, Emrah Eroglu, Roland Malli, Wolfgang F. Graier
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Ca2+ measurements
biosensors
mitochondrial Ca2+
mitochondrial cristae
Ca2+
live cell imaging
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00449/full

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https://www.frontiersin.org/article/10.3389/fncel.2019.00449/full

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