The genomic landscape of human cellular circadian variation points to a novel role for the signalosome

The genomic landscape of human cellular circadian variation points to a novel role for the signalosome

The importance of natural gene expression variation for human behavior is undisputed, but its impact on circadian physiology remains mostly unexplored. Using umbilical cord fibroblasts, we have determined by genome-wide association how common genetic variation impacts upon cellular circadian functio...

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Bibliographic Details
Main Authors: Ludmila Gaspar, Cedric Howald, Konstantin Popadin, Bert Maier, Daniel Mauvoisin, Ermanno Moriggi, Maria Gutierrez-Arcelus, Emilie Falconnet, Christelle Borel, Dieter Kunz, Achim Kramer, Frederic Gachon, Emmanouil T Dermitzakis, Stylianos E Antonarakis, Steven A Brown
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-09-01
Series:eLife
Subjects:
circadian
fibroblast
signalosome
genetic variation
genome-wide association
protein stability
Online Access:https://elifesciences.org/articles/24994

Internet

https://elifesciences.org/articles/24994

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