Gata2-L359V impairs primitive and definitive hematopoiesis and blocks cell differentiation in murine chronic myelogenous leukemia model

Gata2-L359V impairs primitive and definitive hematopoiesis and blocks cell differentiation in murine chronic myelogenous leukemia model

Abstract GATA2, a key transcription factor in hematopoiesis, is frequently mutated in hematopoietic malignancies. How the GATA2 mutants contribute to hematopoiesis and malignant transformation remains largely unexplored. Here, we report that Gata2-L359V mutation impeded hematopoietic differentiation...

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Bibliographic Details
Main Authors: Ya-Kai Fu, Yun Tan, Bo Wu, Yu-Ting Dai, Xiao-Guang Xu, Meng-Meng Pan, Zhi-Wei Chen, Niu Qiao, Jing Wu, Lu Jiang, Jing Lu, Bing Chen, Avigail Rein, Shai Izraeli, Xiao-Jian Sun, Jin-Yan Huang, Qiu-Hua Huang, Zhu Chen, Sai-Juan Chen
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03826-1

Internet

https://doi.org/10.1038/s41419-021-03826-1

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