Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease

Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease

Dysregulation of intracellular calcium is reported in Alzheimer’s disease. Here the authors show that loss of the mitochondrial Na+ /Ca2 + exchanger, NCLX – primary route of mitochondrial calcium efflux, precedes neuronal pathology in experimental models and contributes to Alzheimer’s disease progre...

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Bibliographic Details
Main Authors: Pooja Jadiya, Devin W. Kolmetzky, Dhanendra Tomar, Antonio Di Meco, Alyssa A. Lombardi, Jonathan P. Lambert, Timothy S. Luongo, Marthe H. Ludtmann, Domenico Praticò, John W. Elrod
Format: Article
Language:English
Published: Nature Publishing Group 2019-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11813-6

Internet

https://doi.org/10.1038/s41467-019-11813-6

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