Stability across the Whole Nuclear Genome in the Presence and Absence of DNA Mismatch Repair

Stability across the Whole Nuclear Genome in the Presence and Absence of DNA Mismatch Repair

We describe the contribution of DNA mismatch repair (MMR) to the stability of the eukaryotic nuclear genome as determined by whole-genome sequencing. To date, wild-type nuclear genome mutation rates are known for over 40 eukaryotic species, while measurements in mismatch repair-defective organisms a...

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Bibliographic Details
Main Authors: Scott Alexander Lujan, Thomas A. Kunkel
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cells
Subjects:
mutation accumulation
mutagenesis
mutation rate
DNA replication
genome stability
DNA mismatch repair
Online Access:https://www.mdpi.com/2073-4409/10/5/1224

Internet

https://www.mdpi.com/2073-4409/10/5/1224

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