Galectin-1 Overexpression Activates the FAK/PI3K/AKT/mTOR Pathway and Is Correlated with Upper Urinary Urothelial Carcinoma Progression and Survival

Galectin-1 Overexpression Activates the FAK/PI3K/AKT/mTOR Pathway and Is Correlated with Upper Urinary Urothelial Carcinoma Progression and Survival

Galectin-1 (GAL1) is a β-galactoside-binding protein involved in multiple aspects of tumorigenesis. However, the biological role of GAL1 in upper tract urothelial carcinoma (UTUC) has not been entirely understood. Herein, we investigated the oncological effects of GAL1 expression in tumor s...

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Bibliographic Details
Main Authors: Yu-Li Su, Hao-Lun Luo, Chun-Chieh Huang, Ting-Ting Liu, Eng-Yen Huang, Ming-Tse Sung, Jen-Jie Lin, Po-Hui Chiang, Yen-Ta Chen, Chih-Hsiung Kang, Yuan-Tso Cheng
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cells
Subjects:
galectin-1
upper urinary urothelial carcinoma
epithelial–mesenchymal transition
survival
phosphoinositide 3-kinases
focal adhesion kinase
mammalian target of rapamycin
Online Access:https://www.mdpi.com/2073-4409/9/4/806

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https://www.mdpi.com/2073-4409/9/4/806

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