Genetic ablation of the mammalian sterile-20 like kinase 1 (Mst1) improves cell reprogramming efficiency and increases induced pluripotent stem cell proliferation and survival

Genetic ablation of the mammalian sterile-20 like kinase 1 (Mst1) improves cell reprogramming efficiency and increases induced pluripotent stem cell proliferation and survival

Adult fibroblasts can be reprogrammed into induced pluripotent stem cells (iPSC) for use in various applications. However, there are challenges in iPSC generation including low reprogramming efficiency, yield, cell survival and viability. Since the Hippo signalling pathway is a key pathway involved...

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Bibliographic Details
Main Authors: Abigail Robertson, Tamer M.A. Mohamed, Zeinab El Maadawi, Nicholas Stafford, Thuy Bui, Dae-Sik Lim, Elizabeth J. Cartwright, Delvac Oceandy
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:Stem Cell Research
Subjects:
Hippo pathway
Reprogramming
iPSC
Mst1
Cell proliferation
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506117300259

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http://www.sciencedirect.com/science/article/pii/S1873506117300259

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