Squalene Selectively Protects Mouse Bone Marrow Progenitors Against Cisplatin and Carboplatin-Induced Cytotoxicity In Vivo Without Protecting Tumor Growth

Squalene Selectively Protects Mouse Bone Marrow Progenitors Against Cisplatin and Carboplatin-Induced Cytotoxicity In Vivo Without Protecting Tumor Growth

Squalene, an isoprenoid antioxidant is a potential cytoprotective agent against chemotherapy-induced toxicity. We have previously published that squalene protects light-density bone marrow cells against cis-diamminedichloroplatinum( II) (cisplatin)-induced toxicity without protecting tumor cells in...

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Bibliographic Details
Main Authors: Bikul Das, Roula Antoon, Rika Tsuchida, Shamim Lotfi, Olena Morozova, Walid Farhat, David Malkin, Gideon Koren, Herman Yeger, Sylvain Baruchel
Format: Article
Language:English
Published: Elsevier 2008-10-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558608801017

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http://www.sciencedirect.com/science/article/pii/S1476558608801017

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