Aging-related changes in the nigrostriatal dopamine system and the response to MPTP in nonhuman primates: Diminished compensatory mechanisms as a prelude to parkinsonism

Aging-related changes in the nigrostriatal dopamine system and the response to MPTP in nonhuman primates: Diminished compensatory mechanisms as a prelude to parkinsonism

Aging is the most prominent risk factor for Parkinson’s disease. Yet, consensus of how advancing age may predispose the dopamine (DA) system to parkinsonism is lacking. Three age ranges of female rhesus monkeys, 8–9, 15–17, and 21–31 years, received unilateral DA depletion with intracarotid 1-methyl...

Full description

Bibliographic Details
Main Authors: Timothy J. Collier, Jack Lipton, Brian F. Daley, Stephane Palfi, Yaping Chu, Caryl Sortwell, Roy A.E. Bakay, John R. Sladek, Jr., Jeffrey H. Kordower
Format: Article
Language:English
Published: Elsevier 2007-04-01
Series:Neurobiology of Disease
Subjects:
Aging
Dopamine
Substantia nigra
Parkinsonism
MPTP
Monkey
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106003093

Internet

http://www.sciencedirect.com/science/article/pii/S0969996106003093

Similar Items