Evidence for an essential deglycosylation-independent activity of PNGase in Drosophila melanogaster.

Evidence for an essential deglycosylation-independent activity of PNGase in Drosophila melanogaster.

BACKGROUND: Peptide:N-glycanase (PNGase) is an enzyme which releases N-linked glycans from glycopeptides/glycoproteins. This enzyme plays a role in the ER-associated degradation (ERAD) pathway in yeast and mice, but the biological importance of this activity remains unknown. PRINCIPAL FINDINGS: In t...

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Bibliographic Details
Main Authors: Yoko Funakoshi, Yuki Negishi, J Peter Gergen, Junichi Seino, Kumiko Ishii, William J Lennarz, Ichiro Matsuo, Yukishige Ito, Naoyuki Taniguchi, Tadashi Suzuki
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2866665?pdf=render

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http://europepmc.org/articles/PMC2866665?pdf=render

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