Conformational flexibility determines the Nf2/merlin tumor suppressor functions

The Neurofibromatosis type 2 gene encodes the Nf2/merlin tumor suppressor protein that is responsible for the regulation of cell proliferation. Once activated, Nf2/merlin modulates adhesive signaling pathways and thereby inhibits cell growth. Nf2/merlin controls oncogenic gene expression by modulati...

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Bibliographic Details
Main Authors: Marina C. Primi, Erumbi S. Rangarajan, Dipak N. Patil, Tina Izard
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Matrix Biology Plus
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2590028521000181