Alphitolic acid, an anti-inflammatory triterpene, induces apoptosis and autophagy in oral squamous cell carcinoma cells, in part, through a p53-dependent pathway

Alphitolic acid, an anti-inflammatory triterpene, induces apoptosis and autophagy in oral squamous cell carcinoma cells, in part, through a p53-dependent pathway

The antitumour mechanism of alphitolic acid (ALA), an anti-inflammatory triterpene, in oral squamous cell carcinoma (OSCC) cells was investigated. ALA suppressed the proliferation of SCC4 and SCC2095 OSCC cells with IC50 values of 12 and 15 µM, respectively, via apoptotic induction. Mechanistically,...

Full description

Bibliographic Details
Main Authors: Li-Yuan Bai, Chang-Fang Chiu, Shih-Jiuan Chiu, Yu-Wen Chen, Jing-Lan Hu, Chia-Yung Wu, Jing-Ru Weng
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Journal of Functional Foods
Subjects:
Alphitolic acid
Oral squamous cell carcinoma
Apoptosis
Autophagy
p53
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464615003758

Internet

http://www.sciencedirect.com/science/article/pii/S1756464615003758

Similar Items