In Vitro Evaluation of Novel Inhibitors against the NS2B-NS3 Protease of Dengue Fever Virus Type 4

In Vitro Evaluation of Novel Inhibitors against the NS2B-NS3 Protease of Dengue Fever Virus Type 4

The discovery of potent therapeutic compounds against dengue virus is urgently needed. The NS2B-NS3 protease (NS2B-NS3pro) of dengue fever virus carries out all enzymatic activities needed for polyprotein processing and is considered to be amenable to antiviral inhibition by analogy. Virtual screeni...

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Bibliographic Details
Main Authors: Thi Thanh Hanh Nguyen, Sun Lee, Hsi-Kai Wang, Hsin-Yen Chen, Ying-Ta Wu, Simon C. Lin, Do-Won Kim, Doman Kim
Format: Article
Language:English
Published: MDPI AG 2013-12-01
Series:Molecules
Subjects:
dengue fever
inhibitors
NS2B-NS3 protease
virtual screening
Online Access:http://www.mdpi.com/1420-3049/18/12/15600

Internet

http://www.mdpi.com/1420-3049/18/12/15600

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