Global DNA Hypomethylation in Epithelial Ovarian Cancer: Passive Demethylation and Association with Genomic Instability

Global DNA Hypomethylation in Epithelial Ovarian Cancer: Passive Demethylation and Association with Genomic Instability

A hallmark of human cancer is global DNA hypomethylation (GDHO), but the mechanisms accounting for this defect and its pathological consequences have not been investigated in human epithelial ovarian cancer (EOC). In EOC, GDHO was associated with advanced disease and reduced overall and disease-free...

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Bibliographic Details
Main Authors: Wa Zhang, David Klinkebiel, Carter J. Barger, Sanjit Pandey, Chittibabu Guda, Austin Miller, Stacey N. Akers, Kunle Odunsi, Adam R. Karpf
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cancers
Subjects:
dna hypomethylation
epithelial ovarian cancer
gene expression
repetitive elements
genomic instability
dnmts
Online Access:https://www.mdpi.com/2072-6694/12/3/764

Internet

https://www.mdpi.com/2072-6694/12/3/764

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