Cholinesterase inhibitors influence APP metabolism in Alzheimer disease patients

Cholinesterase inhibitors influence APP metabolism in Alzheimer disease patients

Platelets mirror pathogenic alterations in the central nervous system of Alzheimer disease (AD) patients: an alteration of the Amyloid Precursor Protein (APP) forms pattern and decreased alpha-secretase activity – the non-amyloidogenic APP processing enzyme – were demonstrated. Platelets were analys...

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Bibliographic Details
Main Authors: Martina Zimmermann, Barbara Borroni, Flaminio Cattabeni, Alessandro Padovani, Monica Di Luca
Format: Article
Language:English
Published: Elsevier 2005-06-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Platelets
APP metabolism
Cholinesterase inhibitors
Alpha-secretase
Beta-secretase
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105000057

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http://www.sciencedirect.com/science/article/pii/S0969996105000057

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