Emodin Rescues Intrahepatic Cholestasis via Stimulating FXR/BSEP Pathway in Promoting the Canalicular Export of Accumulated Bile

Emodin Rescues Intrahepatic Cholestasis via Stimulating FXR/BSEP Pathway in Promoting the Canalicular Export of Accumulated Bile

AimBile salt export pump (BSEP) have been confirmed to play an important role for bile acid canalicular export in the treatment of cholestasis. In this study, we investigated the stimulatory effect of emodin on BSEP signaling pathway in cholestasis.MethodsCell and animal experiments were given diffe...

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Bibliographic Details
Main Authors: Xiao-Li Xiong, Yan Ding, Zhi-Lin Chen, Yao Wang, Pan Liu, Huan Qin, Li-Shan Zhou, Ling-Ling Zhang, Juan Huang, Lei Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Pharmacology
Subjects:
emodin
cholestasis
bile salt export pump
signaling pathway
upregulation
downregulation
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00522/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00522/full

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