Safety and efficacy of cyclooxygenase-2 inhibition for treatment of primary hypertrophic osteoarthropathy: A single-arm intervention trial

Background: Primary hypertrophic osteoarthropathy (PHO) is a rare disease involving joint, bone and skin. Two underlying genes responsible for this disease—hydroxyprostaglandin dehydrogenase (HPGD) and solute carrier organic anion transporter family, member 2A1 (SLCO2A1)—are both associated with abe...

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Bibliographic Details
Main Authors: Lu Yuan, Ruo-xi Liao, Yuan-yuan Lin, Yan Jiang, Ou Wang, Mei Li, Xiao-ping Xing, Qian-qian Pang, Evelyn Hsieh, Wei-bo Xia
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Journal of Orthopaedic Translation
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X18301013