7,8-Dihydroxyflavone Ameliorates Cognitive Impairment by Inhibiting Expression of Tau Pathology in ApoE-Knockout Mice

7,8-Dihydroxyflavone Ameliorates Cognitive Impairment by Inhibiting Expression of Tau Pathology in ApoE-Knockout Mice

7,8-Dihydroxyflavone (7,8-DHF), a tyrosine kinase B (TrkB) agonist that mimics the neuroprotective properties of brain-derived neurotrophic factor, which can not efficiently deliver into the brain, has been reported to be useful in ameliorating cognitive impairment in many diseases. Researches have...

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Bibliographic Details
Main Authors: Yang Tan, Shu Ke Nie, Wen De Zhu, Fang Liu, Hai Long Guo, Xue Bing Cao, Jie Wen Chu, Xing Jun Jiang, Yun Jian Zhang, Yu Zhen Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Aging Neuroscience
Subjects:
cognitive impairment
protein kinase B
tau pathology
glycogen synthase kinase-3β
neuroprotective
Asparaginyl endopeptidase
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00287/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00287/full

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