Allopregnanolone: From molecular pathophysiology to therapeutics. A historical perspective

Allopregnanolone: From molecular pathophysiology to therapeutics. A historical perspective

Allopregnanolone is synthesized in the central nervous system either de novo from cholesterol or from steroid hormone precursors like progesterone and pregnenolone. Over the past 30 years, direct and rapid, non-genomic actions of allopregnanolone and its derivatives via GABAA receptors have been dem...

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Bibliographic Details
Main Authors: Steven M Paul, Graziano Pinna, Alessandro Guidotti
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Neurobiology of Stress
Subjects:
Postpartum depression
GABAA receptors
Neurosteroids
Allopregnanolone
Brexanolone
Zulresso
Online Access:http://www.sciencedirect.com/science/article/pii/S2352289520300059

Internet

http://www.sciencedirect.com/science/article/pii/S2352289520300059

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