HLA Upregulation During Dengue Virus Infection Suppresses the Natural Killer Cell Response

HLA Upregulation During Dengue Virus Infection Suppresses the Natural Killer Cell Response

Dengue virus (DENV) is the most prevalent mosquito-borne virus in the world and a major cause of morbidity in the tropics and subtropics. Upregulation of HLA class I molecules has long been considered a feature of DENV infection, yet this has not been evaluated in the setting of natural infection. N...

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Bibliographic Details
Main Authors: Julia L. McKechnie, Davis Beltrán, Arcelys Pitti, Lisseth Saenz, Ana B. Araúz, Rosemary Vergara, Eva Harris, Lewis L. Lanier, Catherine A. Blish, Sandra López-Vergès
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
dengue virus
anti-viral response
human leukocyte antigen class I
HLA-E
natural killer cells
monocytes
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2019.00268/full

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https://www.frontiersin.org/article/10.3389/fcimb.2019.00268/full

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